Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 14 4 2025 10 01 Antihypertensive efficacy of allopurinol; a mini-review on current concepts e27587 e27587 10.34172/jnp.2025.27587 EN Ali Thoulfikar A. Imeer https://orcid.org/0000-0003-0842-1072 Abdul Amir H. Kadhum https://orcid.org/0000-0003-4074-9123 Qais R. Lahhob https://orcid.org/0000-0001-5259-8946 Hussein Ali Al-Bahrani https://orcid.org/0000-0002-9637-3359 Maytham Ahmed Abdul Aemah https://orcid.org/0000-0002-3333-9778 Omer Mansib Kassid https://orcid.org/0000-0001-6459-0773 Journal Article 10.34172/jnp.2025.27587 2024 10 13 2025 01 11 Allopurinol, primarily used to treat gout, has shown potential as an antihypertensive agent due to its effects on oxidative stress and endothelial function. This agent is not typically used as a first-line treatment for hypertension; however, some studies have suggested that it may have potential antihypertensive effects. More research is needed to establish its efficacy and mechanisms in treating hypertension.