Society of Diabetic Nephropathy Prevention Journal of Nephropathology 2251-8363 14 3 2025 07 01 Immune aspects of systemic hypertension; a short-review to recent concepts e26570 e26570 10.34172/jnp.2025.26570 EN Rahimeh Eskandarian https://orcid.org/0000-0002-4727-3386 Mohammad Memarian https://orcid.org/0000-0003-4534-3018 Journal Article 10.34172/jnp.2025.26570 2024 08 07 2024 12 23 The renin-angiotensin-aldosterone system (RAAS) and the immune system interact in hypertension through various mechanisms, including inflammation, immune cell infiltration, oxidative stress, and aldosterone-induced hypertension. Further research is needed to fully understand the complex interplay between the RAAS and the immune system in hypertension and to identify potential therapeutic targets. Additionally, T lymphocytes, monocytes, macrophages, dendritic cells, neutrophils, and B lymphocytes are some of the immune cells that have been implicated in hypertension. These immune cells can promote vascular inflammation and remodeling, produce reactive oxygen species and cytokines, and activate the adaptive immune response. Further research is needed to fully understand the role of the immune system in hypertension and to identify potential therapeutic targets.