Membranous nephropathy with collapse in a HIV negative patient; a case report with a 34-month follow-up

Luisa Lemos Costa; Ana Isabel Rodrigues; Carolina Ferreira; Carla Pereira Lima; Tânia Couto Sousa; Helena Viana; Mário Góis; Sérgio Silva Lemos

doi:10.34172/jnp.2022.17337

doi: 10.34172/jnp.2022.17337

Abstract View: 1152

Case Report

Membranous nephropathy with collapse in a HIV negative patient; a case report with a 34-month follow-up

Luisa Lemos Costa ¹^* , Ana Isabel Rodrigues ¹ , Carolina Ferreira ¹ , Carla Pereira Lima ¹ , Tânia Couto Sousa ¹ , Helena Viana ² , Mário Góis ² , Sérgio Silva Lemos ¹

¹ Nephrology Department, Centro Hospitalar Tondela Viseu, Viseu, Portugal
² Nephrology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

*Corresponding author: Luisa Lemos Costa, Email: luisalemosccosta@gmail.com, 7886@hstviseu.min-saude.pt

Abstract

Membranous nephropathy (MN) is a common cause of nephrotic syndrome (NS) in nondiabetic adults. Collapsing nephropathy (CN) is a morphological pattern that is usually classified as a variant of focal segmental glomerulosclerosis (cFSGS). The simultaneous presence of both MN and CN is rare and their combination usually foresees an unfavorable outcome. Herein, we describe a case report of a patient with PLA₂ R-associated MN with collapse, its treatment and clinical course.

Keywords: Membranous nephropathy, Collapsing variant, Nephropathology, Podocytopathy, Immunosuppressive therapy, Rituximab

Implication for health policy/practice/research/medical education:

The coexistence of CN and MN is a rare finding. This case highlights its difficult management and the potential benefit of rituximab administration in this rare entity of kidney disease.

Please cite this paper as: Costa LL, Rodrigues AI, Ferreira C, Lima CP, Sousa TC, Viana H, Góis M, Lemos SS. Membranous nephropathy with collapse in a HIV negative patient; a case report with a 34-month follow-up. J Nephropathol. 2022;11(x):exx. DOI: 10.34172/ jnp.2022.xx.

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