J Nephropathol. 2017;6(4): 395-398.
doi: 10.15171/jnp.2017.65

Scopus ID: 85046550513
  Abstract View: 1874
  PDF Download: 868

Original Article

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Shirin Asgharian 1, Zahra Lorigooini 1, Reza Rafieian 2, Mahmoud Rafieian-Kopaei 1 * , Soleiman Kheiri 3, Hamid Nasri 4

1 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Student’s Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Biostatistics and Epidemiology, Faculty of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Ph.D, rafieian@yahoo.com


Background: Oxygen free radicals are known as one of the causes of kidney injury. Therefore,
Berberis vulgaris which has high level of antioxidant activity may be able to prevent this
injury by elimination of free radicals.

Objectives: This study was aimed to investigate the protective effect of B. vulgaris extract on
contrast media-induced nephrotoxicity.

Materials and Methods: To conduct this experimental study, 30 male rats were randomized to
three groups; Control, contrast media, and contrast media + B. vulgaris extract. After the
treatment, histopathological damages to the kidney tissues were comparatively studied.

Results: Tissue damage was greater in the contrast media-treated group than the other
two groups (P < 0.001). In group treated with B. vulgaris extract, the rate of tissue damage
deceased significantly (P < 0.001).

Conclusions: This study showed the positive effects of B. vulgaris on contrast media-induced
nephrotoxicity. This inexpensive and non-toxic medicinal plant might be used as an
effective agent for people at risk of contrast-induced acute kidney injury (CI-AKI).

Keywords: Berberis vulgaris, Contrast, Kidney injury, Rat

Implication for health policy/practice/research/medical education:

The results showed the protective effect of B. vulgaris in improving contrast media-induced damage to kidney tissue. Therefore,
it might be beneficial in these patients. However, further studies are needed to confirm this and to determine the most suitable doses of B. vulgaris extract.

Please cite this paper as: Asgharian S, Lorigooini Z, Rafieian R, Rafieian-Kopaei M, Kheiri S, Nasri H. The preventive effect of Berberis vulgaris extract on contrast-induced acute kidney injury. J Nephropathol. 2017;6(4):395-398. DOI: 10.15171/jnp.2017.65.

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Submitted: 10 Apr 2017
Accepted: 08 Aug 2017
ePublished: 24 Aug 2017
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