ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2014;3(1):29-33.
doi:10.12860/jnp.2014.07
PMID: 24644541
PMCID: PMC3956905

Scopus id: 84895951879

Original Article

Impact of oral vitamin D (cholecalciferol) replacement therapy on blood pressure in type 2 diabetes patients; a randomized, double-blind, placebo controlled clinical trial

Hamid Nasri 1, Saeed Behradmanesh 2, Ali Ahmadi 3, Mahmoud Rafieian-Kopaei 4 *

1 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Corresponding author: Prof. Mahmoud Rafieian-kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Email: rafieian@yahoo.com Email: rafieian@yahoo.com

Abstract

Background: Vitamin D is an important mediator of calcium metabolism. It has also been implicated as a potential contributor to the pathophysiology of various extra-skeletal conditions, consisting hypertension, renal disease, and insulin resistance.

Objectives: The primary objective of this study was to determine whether oral vitamin D (cholecalciferol) supplementation can lead to improvement of blood pressure in type 2 diabetes patients.

Patients and Methods: This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks. Serum 25-Hydroxy vitamin D [25(OH)D] level was measured with ELISA method.

Results: Five patients (8.3%) had vitamin D deficiency, 27 (45%) had insufficient levels of vitamin D and in 28 (45%) patients vitamin D level was within normal limits. The means of systolic blood pressure (BP) and diastolic BP in patients before intervention were 121 and 80.5 mmHg; after intervention they were 110 and 76.3 mmHg, respectively. After intervention, systolic and diastolic blood pressure levels were significantly less than control group (p< 0.01).

Conclusions: In this study we found that weekly vitamin D supplementation (cholecalciferol; 50,000 units for 12 weeks) had beneficial effect on the level of blood pressure in type 2 diabetic patients. Thus, oral vitamin D may help in improvement of hypertension in these patients.

Implication for health policy/practice/research/medical education:

In this study we found that weekly vitamin D supplementation (cholecalciferol; 50,000 units for 12 weeks) had beneficial effect on level of blood pressure in type 2 diabetic patients. Thus, oral vitamin D may help in improvement of hypertension in these patients.

Please cite this paper as: Nasri H, Behradmanesh S, Ahmadi A, Rafieian-Kopaei M. Impact of oral vitamin D (cholecalciferol) replacement therapy on blood pressure in type 2 diabetes patients; a randomized, double- blind, placebo controlled clinical trial. J Nephropathol. 2014; 3(1): 29-33. DOI: 10.12860/jnp.2014.07

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First published online: 01 Jan 2014
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