ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2013;2(1):20-27.
doi:10.5812/nephropathol.9093
PMID: 24475422
PMCID: PMC3886179

Scopus id: 84874723278

Review Article

Diabetic nephropathy and antioxidants

Abstract

Context: Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects.

Conclusions: Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies.

Implication for health policy/practice/research/medical education:

Treatment of diabetic nephropathy (DN) in human by rennin angiotensin system blockers is inadequate and antioxidants ought to couple with this treatment. Classical antioxidants have not shown beneficial effect in diabetic patients. New multi -property antioxidants may be ameliorate human DN that show high power antioxidant capacity, anti inflammatory effect, long half-life time, high permeability to mitochondrion and improve body antioxidants enzyme activity. Rosmarinic acid, multi properties antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies.

Please cite this paper as: Tavafi M. Diabetic nephropathy and antioxidants. J Nephropathology. 2013; 2(1): 20-27. DOI: 10.5812/nephropathol.9093

First name
 
Last name
 
Email address
 
Comments
 
Security code





First published online: 01 Jan 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Abstract Page Views: 2902
PDF Downloads: 1603
Full Text Views: 0